Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

Carotenoids are currently investigated regarding their potential to lower the risk of chronic
disease and to combat vitamin A deficiency. Surprisingly, responses to dietary …

Cancer stem-like cells (CSCs) are a rare subpopulation of cancer cells capable of
propagating the disease and causing cancer recurrence. In this study, we found that the …

Background Alterations of PTEN, regulator of the PTEN/PI3K-AKT pathway, are common in
several types of cancer. This study aimed to do comprehensive analysis of PTEN in …

Dysregulation of microRNAs has been reported to be involved in the progression of human
colorectal cancers (CRCs). Loss of the adenomatous polyposis coli (APC) gene is a …

Uterine endometrioid carcinoma is the most common neoplastic disease in the female
genital tract and develops from a common precursor lesion, atypical hyperplasia …

Colorectal cancer (CRC) is characterized by specific patterns of copy number alterations
(CNAs), which helped with the identification of driver oncogenes and tumor suppressor …

Aims: To investigate the association of phosphatase and tensin homologue deleted on
chromosome ten (PTEN) gene rs3830675, and additional interaction with drinking and …

Genetically synthetic lethality occurs when an organism uniquely carries two deleterious, but
non-lethal, genetic alterations, whose combined effects is to induce lethality in the organism …

Our current understanding of pituitary adenoma (PA) pathobiology is limited. Thus, the
purpose of this project is to gain a better understanding of PA biology through the …