Background Evidence-based medicine (EBM) has always required integration of patient
values with 'best'clinical evidence. It is widely recognized that scientific practices and …

Importance Hypertension treatment is beneficial for most hypertensive patients. The benefits
for patients who are very old and frail, especially those taking numerous medications, are …

The positive benefit–risk ratio of most drugs is decreasing in correlation to very old age, the
extent of comorbidity, dementia, frailty and limited life expectancy (VOCODFLEX). First, we …

Objectives: To investigate medication changes for older patients admitted to hospital and to
explore associations between patient characteristics and polypharmacy. Design …

The accumulation of deficits with increasing age results in a decline in the functional
capacity of multiple organs and systems. These changes can have a significant influence on …

The risks of polypharmacy are heightened in the elderly because of a number of factors
including age-related physiologic changes and the presence of comorbid conditions …

Diagnosing and treating hypertension plays an important role in minimising the risk of
cardiovascular disease and stroke. Early and accurate diagnosis of hypertension, as well as …

Research into the prevalence and impact of low-value medical practices has evolved
substantially over the past two decades. However, despite international efforts, many …

Objectives Our aim was to explore junior doctors' attitudes and awareness around concepts
related to medication review, in order to find ways to change the culture for reviewing …

Several observational studies have demonstrated that statins continue to be prescribed for
patients with limited life expectancy. In one study, 2 up to 62% of patients with cancer and a …