The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis
WH Anderson, RD Coakley, B Button… - American journal of …, 2015 - atsjournals.org
Rationale: Chronic bronchitis (CB) is characterized by persistent cough and sputum
production. Studies were performed to test whether mucus hyperconcentration and …
production. Studies were performed to test whether mucus hyperconcentration and …
Continuous mucociliary transport by primary human airway epithelial cells in vitro
PR Sears, WN Yin… - American Journal of …, 2015 - journals.physiology.org
Mucociliary clearance (MCC) is an important innate defense mechanism that continuously
removes inhaled pathogens and particulates from the airways. Normal MCC is essential for …
removes inhaled pathogens and particulates from the airways. Normal MCC is essential for …
Baseline goblet cell mucin secretion in the airways exceeds stimulated secretion over extended time periods, and is sensitive to shear stress and intracellular mucin …
Y Zhu, LH Abdullah, SP Doyle, K Nguyen… - PloS one, 2015 - journals.plos.org
Airway mucin secretion studies have focused on goblet cell responses to exogenous
agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial …
agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial …
Patient-specific modeling of regional antibiotic concentration levels in airways of patients with cystic fibrosis: are we dosing high enough?
AC Bos, C Van Holsbeke, JW De Backer… - PLoS …, 2015 - journals.plos.org
Background Pseudomonas aeruginosa (Pa) infection is an important contributor to the
progression of cystic fibrosis (CF) lung disease. The cornerstone treatment for Pa infection is …
progression of cystic fibrosis (CF) lung disease. The cornerstone treatment for Pa infection is …
Thick airway surface liquid volume and weak mucin expression in pendrin‐deficient human airway epithelia
HJ Lee, JE Yoo, W Namkung, HJ Cho… - Physiological …, 2015 - Wiley Online Library
Pendrin is an anion exchanger whose mutations are known to cause hearing loss. However,
recent data support the linkage between pendrin expression and airway diseases, such as …
recent data support the linkage between pendrin expression and airway diseases, such as …
Novel role of cystic fibrosis transmembrane conductance regulator in maintaining adult mouse olfactory neuronal homeostasis
S Pfister, T Weber, W Härtig… - Journal of …, 2015 - Wiley Online Library
The olfactory epithelium (OE) of mice deficient in cystic fibrosis transmembrane conductance
regulator (CFTR) exhibits ion transport deficiencies reported in human CF airways, as well …
regulator (CFTR) exhibits ion transport deficiencies reported in human CF airways, as well …
[HTML][HTML] Mechanosensitive activation of CFTR by increased cell volume and hydrostatic pressure but not shear stress
C Vitzthum, WG Clauss, M Fronius - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl− channel that is
essential for electrolyte and fluid homeostasis. Preliminary evidence indicates that CFTR is a …
essential for electrolyte and fluid homeostasis. Preliminary evidence indicates that CFTR is a …
On the pathogenesis of acute exacerbations of mucoobstructive lung diseases
RC Boucher - Annals of the American Thoracic Society, 2015 - atsjournals.org
Mucoobstructive lung diseases have highlighted the importance of a proper description of
the normal mucus clearance system. A useful description of the normal mucus clearance …
the normal mucus clearance system. A useful description of the normal mucus clearance …
A numerical study of water loss rate distributions in MDCT-based human airway models
Abstract Both three-dimensional (3D) and one-dimensional (1D) computational fluid
dynamics methods are applied to study regional water loss in three multi-detector row …
dynamics methods are applied to study regional water loss in three multi-detector row …
The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue
X Xu, L Li, C Wang, Y Liu, C Chen, J Yan, H Ding… - Cell & Bioscience, 2015 - Springer
Background I t is established that adipose-derived stem cells (ADSCs) produce and secrete
cytokines/growth factors that antagonize mucosal injury. However, the exact molecular basis …
cytokines/growth factors that antagonize mucosal injury. However, the exact molecular basis …