Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

L Wollin, E Wex, A Pautsch, G Schnapp… - European …, 2015 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …

Cellular interactions in the pathogenesis of interstitial lung diseases

G Bagnato, S Harari - European Respiratory Review, 2015 - Eur Respiratory Soc
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological
conditions that share similar clinical, radiological and pathological manifestations, despite …

The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis

F Grimminger, A Günther… - European Respiratory …, 2015 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a median survival time
from diagnosis of 2–3 years. Although the pathogenic pathways have not been fully …

Telomere length in interstitial lung diseases

R Snetselaar, CHM Van Moorsel, KM Kazemier… - Chest, 2015 - Elsevier
BACKGROUND Interstitial lung disease (ILD) is a heterogeneous group of rare diseases
that primarily affect the pulmonary interstitium. Studies have implicated a role for telomere …

Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis

MW Foster, LD Morrison, JL Todd… - Journal of proteome …, 2015 - ACS Publications
The proteomic analysis of bronchoalveolar lavage fluid (BALF) can give insight into
pulmonary disease pathology and response to therapy. Here, we describe the first gel-free …

Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis

S Cicko, M Grimm, K Ayata, J Beckert, A Meyer… - Respiratory …, 2015 - Springer
Rationale Pulmonary fibrosis is a progressive disease with only few treatment options
available at the moment. Recently, the nucleoside uridine has been shown to exert anti …

Roflumilast prevents the metabolic effects of bleomycin-induced fibrosis in a murine model

J Milara, E Morcillo, D Monleon, H Tenor, J Cortijo - PLoS One, 2015 - journals.plos.org
Fibrotic remodeling is a process common to chronic lung diseases such as chronic
obstructive pulmonary disease (COPD), pulmonary fibrosis, acute respiratory distress …

[PDF][PDF] A cohort study of Danish patients with interstitial lung diseases

C Hyldgaard - Dan Med J, 2015 - content.ugeskriftet.dk
The field of interstitial lung diseases (ILD) and especially idiopathic pulmonary fibrosis (IPF)
has undergone immense changes during the last ten to fifteen years. The process started …

The role of nailfold capillaroscopy in interstitial lung diseases-can it differentiate idiopathic cases from collagen tissue disease associated interstitial lung diseases?

D Çakmakçi Karadoğan, A Balkarlı, Ö Önal… - Tuberkuloz ve …, 2015 - gcris.pau.edu.tr
Introduction: Nailfold capillaroscopy (NFC) is a non-invasive diagnostic test that is mostly
used for early diagnosis of collagen tissue diseases (CTDs). We aimed to evaluate whether …

Nintedanib: a new treatment for idiopathic pulmonary fibrosis.

V Cottin - 2015 - cabidigitallibrary.org
Nintedanib is an intracellular inhibitor of tyrosine kinases that has recently been approved
as a treatment for idiopathic pulmonary fibrosis (IPF) by regulatory authorities in the USA …