Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …

A robust, often underappreciated, feature of human biology is that women live longer than
men not just in technologically advanced, low-mortality countries such as those in Europe or …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In
contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan. They …

A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …

We utilized induced pluripotent stem cells (iPSCs) derived from Huntington's disease (HD)
patients as a human model of HD and determined that the disease phenotypes only …

Limiting food intake attenuates many of the deleterious effects of aging, impacting upon
healthspan and leading to an increased lifespan. Whether it is the overall restriction of …

The somatotropic signaling pathway has been implicated in aging and longevity studies in
mice and other species. The physiology and lifespans of a variety of mutant mice, both …

In proliferating cells, mTOR is active and promotes cell growth. When the cell cycle is
arrested, then mTOR converts reversible arrest to senescence (geroconversion). Rapamycin …

Gene expression changes during aging are partly conserved across species, and suggest
that oxidative stress, inflammation and proteotoxicity result from mitochondrial malfunction …

Many diets and nutritional advice are circulating, often based on short‐or medium‐term
clinical trials and primary outcomes, like changes in LDL cholesterol or weight. It remains …