Background. The aim of this review is to provide the information about molecular basis of
hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic …

Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell
division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human …

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by accumulation of
malignant plasma cells (PCs) within the bone marrow (BM). The PCs are in close contact …

Resistance to chemotherapy is a major limitation of cancer treatments with several
molecular mechanisms involved, in particular altered local drug metabolism and …

摘要目的探讨缺氧诱导因子-1α (HIF-1α), 凋亡相关蛋白Survivin 在非小细胞肺癌(NSCLC)
中的表达及其与临床病理特征的关系, 以及两种蛋白的相关性. 方法采用免疫组化法检测52 …

Mnohočetný myelom je rozšířené krevní nádorové onemocnění, které vychází z
patologického klonu plazmatických buněk usídlených v kostní dřeni. Onemocnění je obtížně …

The increasing importance of hypoxia-inducible factor-1α (HIF-1α) in tumorigenesis raises
the possibility that agents which specifically inhibit this transcription factor, would provide …

Multiple myeloma is a neoplastic disorder of plasma cells, which accounts for more than
10% of all haematological cancers (Howlader et al. 2011). The development of multiple …

This thesis focuses on biological activity of pyrrole-imidazole polyamides in vivo. The work
presented includes experiments underlining sequence selectivity of these compounds in …