The tremendous clinical success of checkpoint blockers illustrates the potential of
reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in …

Cancer development and its response to therapy are strongly influenced by innate and
adaptive immunity, which either promote or attenuate tumorigenesis and can have opposing …

Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies
has been proposed to be the major effector mechanism in xenograft models. Here, using …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

The immunosurveillance theory postulates that tumors evolve and progress in an
uncontrolled fashion only when anticancer immune responses fail. Natural …

The term “immunogenic cell death”(ICD) is commonly employed to indicate a peculiar
instance of regulated cell death (RCD) that engages the adaptive arm of the immune system …

Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-
associated macrophages (TAMs) infiltrate and adopt different activation states between anti …

The term “immunogenic cell death”(ICD) is now employed to indicate a functionally peculiar
form of apoptosis that is sufficient for immunocompetent hosts to mount an adaptive immune …

The immunogenicity of malignant cells has recently been acknowledged as a critical
determinant of efficacy in cancer therapy. Thus, besides developing direct …

Antitumor immunity driven by intratumoral dendritic cells contributes to the efficacy of
anthracycline-based chemotherapy in cancer. We identified a loss-of-function allele of the …