Cytokines play an important role in host defense against microorganisms. They orchestrate
innate immunity by inducing protective local inflammation and systemic acute phase …

Systemic lupus erythematosus (SLE, lupus) is a highly complex and heterogeneous
autoimmune disease that most often afflicts women in their child-bearing years. It is …

Background The immune system is important in epithelial ovarian cancer (EOC). Interleukin-
6 is associated with chemoresistance and an immune-suppressive tumor microenvironment …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
presence of autoantibodies against nuclear components. Circulating immune complexes of …

Abstract Interleukin (IL)-6 has become a major target for clinical intervention in various
autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) …

Background & Aims Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal
inflammatory cells that participate in chronic intestinal inflammation. We investigated the role …

IL-6 can mediate proinflammatory effects, and IL-6 receptor (IL-6R) blockade as a treatment
for inflammatory diseases has entered clinical practice. However, opposing effects of IL-6 …

Cutaneous lupus erythematosus (CLE) is an inflammatory disease with a broad range of
cutaneous manifestations that may be accompanied by systemic symptoms. The …

Autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis
and inflammatory bowel disease, have complex pathogeneses and the factors which cause …

Drug discovery in systemic lupus erythematosus (SLE) has lagged behind other rheumatic
diseases, in large part because of difficulty in measuring change or improvement in a …