Macrophage polarization between the M2 (repair, protumorigenic) and M1 (inflammatory)
phenotypes is seen as a continuum of states. The detailed transcriptional events and signals …

Brain metastasis is a major cause of morbidity and mortality of lung cancer patients. We
assessed whether aberrant expression of specific microRNAs could contribute to brain …

Growth factors promote tumor growth and metastasis. We found that epidermal growth factor
(EGF) induced a set of 22 microRNAs (miRNAs) before promoting the migration of mammary …

Tumor progression requires cancer cell proliferation, migration, invasion, and attraction of
blood and lymph vessels. These processes are tightly regulated by growth factors and their …

Abstract miRNA expression is deregulated in non-small cell lung cancer (NSCLC), and
some miRNAs are associated with gefitinib sensitivity. Here, we investigated if circulating …

Treatment of EGFR-mutant lung cancer with erlotinib results in dramatic tumor regression
but it is invariably followed by drug resistance. In characterizing early transcriptional …

Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we
identify Navigator‐3 (NAV 3), a gene frequently mutated or deleted in human tumors, as a …

Regulation of small RNAs by other non-coding RNAs is a ubiquitous feature of gene
regulatory systems that can be exploited by viruses. Examples of this have been described …

The immediate-early response mediates cell fate in response to a variety of extracellular
stimuli and is dysregulated in many cancers. However, the specificity of the response across …

The epidermal growth factor (EGF) is responsible for the activation of intracellular signal
transducers that act on cell-cycle progression, cell motility, angiogenesis and inhibition of …