The epidemic nature of diabetes mellitus in different regions is reviewed. The Middle East
and North Africa region has the highest prevalence of diabetes in adults (10.9%) whereas …

The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and
pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes …

Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an
outcome by using genetic variants as instrumental variables, but its validity relies on the …

Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Using a genome-wide screen of 9.6 million genetic variants achieved through 1000
Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases
and 57,574 controls of European ancestry. We identified 49 distinct association signals at …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

Diabetes mellitus (DM) is a metabolic diseases characterized by hyperglycemia due to
insufficient or inefficient insulin secretory response. This chronic disease is a global problem …

Most aspects of energy metabolism display clear variations during day and night. This daily
rhythmicity of metabolic functions, including hormone release, is governed by a circadian …

Most living beings, including humans, must adapt to rhythmically occurring daily changes in
their environment that are generated by the E arth's rotation. In the course of evolution, these …