Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho) physiological bias
The calcium-sensing receptor (CaSR) is a widely expressed G protein-coupled receptor
(GPCR) that mediates numerous tissue-specific functions. Its multiple ligands and diverse …
(GPCR) that mediates numerous tissue-specific functions. Its multiple ligands and diverse …
Cardiovascular pharmacogenomics; state of current knowledge and implementation in practice
Pharmacogenomics (PGx) is the science that examines how an individual's genetic make-up
affects the safety and efficacy of therapeutic drugs. PGx of response to cardiovascular (CV) …
affects the safety and efficacy of therapeutic drugs. PGx of response to cardiovascular (CV) …
The future of pharmacogenetics in the treatment of heart failure
MS Anwar, MZ Iskandar, HM Parry, AS Doney… - …, 2015 - Future Medicine
Heart failure is a common disease with high levels of morbidity and mortality. Current
treatment comprises β-blockers, ACE inhibitors, aldosterone antagonists and diuretics …
treatment comprises β-blockers, ACE inhibitors, aldosterone antagonists and diuretics …
Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the …
Abstract Objectives and Background: We evaluated the ability of 23 genetic variants to
provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical …
provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical …
Efficacy of bisoprolol use in heart failure patients depending on pharmacogenetic profile
MM Udovychenko, JS Rudyk - Український терапевтичний …, 2015 - irbis-nbuv.gov.ua
Objective. To investigate possible relationship between Arg389Gly and Ser49Gly gene
polymorphisms of β1 adrenoreceptors (β1 АР) and cardiodynamic indices in patients with …
polymorphisms of β1 adrenoreceptors (β1 АР) and cardiodynamic indices in patients with …