Evidence suggests that the CXC–chemokine receptor-4 pathway plays a role in cancer cell
homing and metastasis, and thus represents a potential target for cancer therapy. The …

CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Chemokines and their receptors control cell migration during development, immune system
responses, and in numerous diseases, including inflammation and cancer. The structural …

Kaposi's sarcoma-associated herpesvirus (KSHV) primarily persists as a latent episome in
infected cells. During latent infection, only a limited number of viral genes are expressed that …

Highlights•KSHV/HHV8 causes three human diseases: Kaposi Sarcoma, Primary Effusion
Lymphoma and the plasma cell variant of Multicentric Castleman Disease.•These occur …

Kaposi sarcoma (KS) is an unusual vascular tumour caused by an oncogenic‐herpesvirus,
Kaposi sarcoma‐associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV …

Human herpesviruses (HHVs) are widespread infectious pathogens that have been
associated with proliferative and inflammatory diseases. During viral evolution, HHVs have …

Chemoattractant cytokines, or chemokines, are the largest sub-family of cytokines. About 50
distinct chemokines have been identified in humans. Their principal role is to stimulate the …

Highlights•IL-10 signaling is a common target for altering a variety of immune
responses.•High resolution structures reveal how chemokine binding can alter cell signaling …

Chemokines are a burgeoning family of chemotactic cytokines displaying a broad array of
functions such as regulation of homeostatic leukocyte traffic and development, as well as …