Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …

Extracellular matrix, via its receptors the integrins, has emerged as a crucial factor in cancer
development. The α2β1 integrin is a major collagen receptor that is widely expressed and …

Resistance to chemotherapeautic drugs is one of the main obstacles to effective cancer
treatment. Multidrug resistance (MDR) is defined as resistance to structurally and/or …

The overexpression of ATP binding cassette (ABC) transporters makes tumor cells
simultaneously resistant to several cytotoxic drugs. Impairing the energy metabolism of …

Yb3+ and Er3+ co-doped Gd2O3 nanoparticles were synthesized via a simple
homogeneous precipitation method followed by subsequent heat treatment. Morphology …

Teotihuacanin (1), an unusual rearranged clerodane diterpene with a new carbon skeleton
containing a spiro-10/6 bicyclic system, was isolated from the leaves and flowers of Salvia …

Ketonic indeno [1, 2-b] indole-9, 10-dione derivatives, initially designed as human casein
kinase II (CK2) inhibitors, were recently shown to be converted into efficient inhibitors of drug …

Introduction: BCRP/ABCG2 is a polyspecific ATP binding cassette transporter involved in
multidrug resistance of tumors. Compared with P-glycoprotein/ABCB1 only a few inhibitors …

Tumor drug resistance is the leading cause of chemotherapy treatment failure. One of the
more relevant mechanisms is represented by multidrug resistance (MDR) that leads to a …

Purpose Multidrug resistance (MDR) may develop due to a series of adaptive responses
under a new stress conditions, such as chemotherapy. Novel strategies are urgently needed …