Stem cell based therapies for age-related macular degeneration: the promises and the challenges

H Nazari, L Zhang, D Zhu, GJ Chader… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Hurdles to clinical translation of human induced pluripotent stem cells

E Neofytou, CG O'Brien, LA Couture… - The Journal of clinical …, 2015 - Am Soc Clin Investig
Human pluripotent stem cells are known to have the capacity to renew indefinitely, being
intrinsically able to differentiate into many different cell types. These characteristics have …

Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies

JA Heslop, TG Hammond, I Santeramo… - Stem cells …, 2015 - academic.oup.com
The field of stem cell therapeutics is moving ever closer to widespread application in the
clinic. However, despite the undoubted potential held by these therapies, the balance …

Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems

N Desai, P Rambhia, A Gishto - Reproductive Biology and Endocrinology, 2015 - Springer
Human embryonic stem cells (hESC) have emerged as attractive candidates for cell-based
therapies that are capable of restoring lost cell and tissue function. These unique cells are …

Banking on iPSC-is it doable and is it worthwhile

S Solomon, F Pitossi, MS Rao - Stem Cell Reviews and Reports, 2015 - Springer
The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of
protocols for their cell-type specific differentiation have revolutionized studies of diseases …

The safety of human pluripotent stem cells in clinical treatment

OE Simonson, A Domogatskaya, P Volchkov… - Annals of …, 2015 - Taylor & Francis
Human pluripotent stem cells (hPSCs) have practically unlimited proliferation potential and a
capability to differentiate into any cell type in the human body. Since the first derivation in …

Safety of allogeneic bone marrow derived mesenchymal stromal cell therapy in renal transplant recipients: the neptune study

MEJ Reinders, GJ Dreyer, JR Bank, H Roelofs… - Journal of translational …, 2015 - Springer
Background Mesenchymal stromal cells (MSC) may serve as an attractive therapy in renal
transplantation due to their immunosuppressive and reparative properties. While most …

[HTML][HTML] Allogenic banking of dental pulp stem cells for innovative therapeutics

PY Collart-Dutilleul, F Chaubron, J De Vos… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Medical research in regenerative medicine and cell-based therapy has brought encouraging
perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from …

Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

A Higuchi, QD Ling, SS Kumar, Y Chang… - Journal of Materials …, 2015 - pubs.rsc.org
Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced
pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different …

The molecular karyotype of 25 clinical-grade human embryonic stem cell lines

MA Canham, A Van Deusen, DR Brison… - Scientific reports, 2015 - nature.com
The application of human embryonic stem cell (hESC) derivatives to regenerative medicine
is now becoming a reality. Although the vast majority of hESC lines have been derived for …