The ventral pallidum (VP) plays a critical role in the processing and execution of motivated
behaviors. Yet this brain region is often overlooked in published discussions of the …

Adolescence is characterized by heightened risk-taking, including substance misuse. These
behavioral patterns are influenced by ontogenic changes in neurotransmitter systems …

Depression is a core symptom of methamphetamine (METH) withdrawal during the first
several weeks of abstinence. However, the precise mechanisms underlying METH …

Genetic variations in catechol-O-methyltransferase (COMT) that modulate cortical dopamine
have been associated with pleiotropic behavioral effects in humans and mice. Recent data …

Addiction is characterized by maladaptive decision‐making, a loss of control over drug
consumption and habit‐like drug seeking despite adverse consequences. These cognitive …

The spiny dendrites of striatal projection neurons integrate synaptic inputs of different origins
to regulate movement. It has long been known that these dendrites lose spines and display …

Psychostimulants are the first-line treatment in attention deficit/hyperactivity disorder
(ADHD), but their effects on brain development remain poorly understood. In particular …

Abstract Rationale The serotonin 7 receptor (5-HT7-R) is part of a neuro-transmission
system with a proposed role in neural plasticity and in mood, cognitive or sleep regulation …

The cause of schizophrenia (SZ) is unknown and no single region of the brain can be
pinpointed as an area of primary pathology. Rather, SZ results from dysfunction of multiple …

The hyperpolarization-activated cyclic-nucleotide-gated non-selective cation (HCN)
channels play a vital role in the neurological basis underlying nervous system diseases …