Epigenetic regulation by sulforaphane: opportunities for breast and prostate cancer chemoprevention
LL Atwell, LM Beaver, J Shannon, DE Williams… - Current pharmacology …, 2015 - Springer
Sulforaphane (SFN) is a phytochemical derived from cruciferous vegetables that has
multiple molecular targets and anti-cancer properties. Researchers have demonstrated …
multiple molecular targets and anti-cancer properties. Researchers have demonstrated …
Recent advances in cancer therapeutics
N Chessum, K Jones, E Pasqua, M Tucker - Progress in medicinal …, 2015 - Elsevier
In the past 20 years, cancer therapeutics has undergone a paradigm shift away from the
traditional cytotoxic drugs towards the targeting of proteins intimately involved in driving the …
traditional cytotoxic drugs towards the targeting of proteins intimately involved in driving the …
Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation
T Mawatari, I Ninomiya, M Inokuchi… - International …, 2015 - spandidos-publications.com
Breast cancer encompasses a heterogeneous group of diseases at the molecular level. It is
known that chemosensitivity of breast cancer depends on its molecular subtype. We …
known that chemosensitivity of breast cancer depends on its molecular subtype. We …
Combination of proteasome and HDAC inhibitor enhances HPV16 E7-specific CD8+ T cell immune response and antitumor effects in a preclinical cervical cancer …
Background Bortezomib, a proteasome inhibitor and suberoylanilide hydroxamic acid
(SAHA, also known as Vorinostat), a histone deacetylase inhibitor, have been recognized as …
(SAHA, also known as Vorinostat), a histone deacetylase inhibitor, have been recognized as …
[HTML][HTML] Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo
HL Huang, CY Peng, MJ Lai, CH Chen, HY Lee… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Histone deacetylase (HDAC) inhibitor has been a promising therapeutic option in cancer
therapy due to its ability to induce growth arrest, differentiation, and apoptosis. In this study …
therapy due to its ability to induce growth arrest, differentiation, and apoptosis. In this study …
The potential of histone deacetylase inhibitors in breast cancer therapy
N Chatterjee, M Tenniswood - Breast Cancer Management, 2015 - Taylor & Francis
Breast cancer is the second leading cause of cancer-related mortality in women. Despite
improvements in prevention, detection and treatment, breast cancer will be responsible for …
improvements in prevention, detection and treatment, breast cancer will be responsible for …
Low processivity for DNA translocation by the ISWI molecular motor
A Eastlund, G Al-Ani, CJ Fischer - … et Biophysica Acta (BBA)-Proteins and …, 2015 - Elsevier
The motor protein ISWI (Imitation SWItch) is the conserved catalytic ATPase domain of the
ISWI family of chromatin remodelers. Members of the ISWI family are involved in regulating …
ISWI family of chromatin remodelers. Members of the ISWI family are involved in regulating …
MPT0E028 在人類大腸直腸癌與B 細胞淋巴癌之抗癌機轉探討
黃瀚立 - 2015 - tdr.lib.ntu.edu.tw
隨著人民平均壽命延長及生活習慣的改變, 癌症發生率仍持續上升, 根據台灣衛生福利部國民
健康署統計, 癌症已為國人十大死因之首達三十年. 為有效治療癌症, 藥物開發在癌症領域中仍是 …
健康署統計, 癌症已為國人十大死因之首達三十年. 為有效治療癌症, 藥物開發在癌症領域中仍是 …
DNA Methylation
MS Alokail, AM Alenad - A concise review of molecular pathology …, 2015 - books.google.com
DNA methylation is a major epigenetic modification that is strongly involved in the
physiological control of genome expression. Developmental processes and proper …
physiological control of genome expression. Developmental processes and proper …
[HTML][HTML] Integrative analysis of the mutational landscape of mouse and human AML identifies functionally relevant leukemia disease alleles
Abstract t (8; 21) is the most frequent chromosomal abnormality in acute myeloid leukemia
(AML), occurring in 4-12% of adult and 12-30% of pediatric patients. This translocation fuses …
(AML), occurring in 4-12% of adult and 12-30% of pediatric patients. This translocation fuses …