Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Enzymatic depletion of the nonessential amino acid l-Arginine (l-Arg) in patients with cancer
by the administration of a pegylated form of the catabolic enzyme arginase I (peg-Arg I) has …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells that expand during benign and cancer-associated inflammation and are characterized …

Although described for the first time some decades ago, the contribution of the immune
system to the establishment of tumors has not been extensively pursued for a long time …

Abstract Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the
liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by …

Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs
for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors …

In cancer patients, granulocytic myeloid derived suppressor cells (G-MDSCs) expand in
number, infiltrating tumor and lymphatic tissues where they suppress an anti-tumor immune …

Critically ill patients display a state of immunosuppression that has been attributed in part to
decreased plasma arginine concentrations. However, we and other authors have failed to …

Clinical observations of spontaneous disease regression in some renal cell carcinoma
(RCC) patients implicate a role for tumor immunity in controlling this disease. Puzzling …