Fibrin plays an essential role in hemostasis as both the primary product of the coagulation
cascade and the ultimate substrate for fibrinolysis. Fibrinolysis efficiency is greatly …

Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …

Background Traumainduced coagulopathy (TIC) is a disorder of the blood clotting process
that occurs soon after trauma injury. A diagnosis of TIC on admission is associated with …

Fibrinogen is a critical protein for hemostasis and clot formation. However, transfusion
guidelines have variable recommendations for maintaining fibrinogen levels in bleeding …

Introduction The purpose of this study was to re-evaluate the findings of a smaller cohort
study on the functional definition and characteristics of acute traumatic coagulopathy (ATC) …

Background Thromboelastometric evaluation of coagulation might be useful for prediction
and management of bleeding after paediatric cardiac surgery. We tested the hypothesis that …

There has been an increased interest in the use of viscoelastic testing to guide blood
product replacement during the acute resuscitation of the injured patient. Currently, no …

In trauma, hemostatic functions should be maintained appropriately to prevent massive
bleeding. This study elucidated the time-dependent changes in platelet count and …

Massive haemorrhage is common and often associated with high morbidity and mortality.
We perform a systematic review of the literature, with extraction of the recommendations …

Background: The ability to predict transfusion requirements may improve perioperative
bleeding management as an integral part of a patient blood management program …