Biology of bone tissue: structure, function, and factors that influence bone cells

R Florencio-Silva, GRS Sasso… - BioMed research …, 2015 - Wiley Online Library
Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

J Josse, F Velard, SC Gangloff - Frontiers in cellular and infection …, 2015 - frontiersin.org
Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for
bone extracellular matrix formation and resorption. This homeostasis is, in part, altered …

Receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin system in bone and other tissues

W Liu, X Zhang - Molecular Medicine Reports, 2015 - spandidos-publications.com
The receptor activator of nuclear factor‑κB ligand (RANKL)/RANK/osteoprotegerin (OPG)
system was identified in the late 1990s, ending the search for the specific factors expressed …

Bone morphogenetic protein signaling in bone homeostasis

G Sánchez-Duffhues, C Hiepen, P Knaus, P Ten Dijke - Bone, 2015 - Elsevier
Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate

Z Chen, J Yuen, R Crawford, J Chang, C Wu, Y Xiao - Biomaterials, 2015 - Elsevier
Osteoblast lineage cells are direct effectors of osteogenesis and are, therefore, commonly
used to evaluate the in vitro osteogenic capacity of bone substitute materials. This method …

Boon and bane of inflammation in bone tissue regeneration and its link with angiogenesis

K Schmidt-Bleek, BJ Kwee, DJ Mooney… - … Engineering Part B …, 2015 - liebertpub.com
Delayed healing or nonhealing of bone is an important clinical concern. Although bone, one
of the two tissues with scar-free healing capacity, heals in most cases, healing is delayed in …

Intramembranous bone healing process subsequent to tooth extraction in mice: micro-computed tomography, histomorphometric and molecular characterization

AE Vieira, CE Repeke, SB Ferreira Junior, PM Colavite… - PloS one, 2015 - journals.plos.org
Bone tissue has a significant potential for healing, which involves a significant the interplay
between bone and immune cells. While fracture healing represents a useful model to …

[HTML][HTML] Evaluation of the osteoinductive potential of a bio-inspired scaffold mimicking the osteogenic niche for bone augmentation

S Minardi, B Corradetti, F Taraballi, M Sandri… - Biomaterials, 2015 - Elsevier
Augmentation of regenerative osteogenesis represents a premier clinical need, as hundreds
of thousands of patients are left with insufficient healing of bony defects related to a host of …

[HTML][HTML] Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis

KW Kim, HR Kim, BM Kim, ML Cho, SH Lee - The American journal of …, 2015 - Elsevier
This study determined the effect of type 17 helper T-cell (Th17) cytokines on
osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor …

Immune complexes regulate bone metabolism through FcRγ signalling

T Negishi-Koga, HJ Gober, E Sumiya… - Nature …, 2015 - nature.com
Autoantibody production and immune complex (IC) formation are frequently observed in
autoimmune diseases associated with bone loss. However, it has been poorly understood …