50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
Abstract In 1964, Vincent Allfrey and colleagues reported the identification of histone
acetylation and with deep insight proposed a regulatory role for this protein modification in …
acetylation and with deep insight proposed a regulatory role for this protein modification in …
[HTML][HTML] Structure and function insights into the NuRD chromatin remodeling complex
MP Torchy, A Hamiche, BP Klaholz - Cellular and Molecular Life Sciences, 2015 - Springer
Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …
through various chromatin-remodeling complexes such as nucleosome remodeling and …
[PDF][PDF] Systematic discovery of Xist RNA binding proteins
Noncoding RNAs (ncRNAs) function with associated proteins to effect complex structural
and regulatory outcomes. To reveal the composition and dynamics of specific noncoding …
and regulatory outcomes. To reveal the composition and dynamics of specific noncoding …
Roles and activities of chromatin remodeling ATP ases in plants
Chromatin remodeling ATP ases and their associated complexes can alter the accessibility
of the genome in the context of chromatin by using energy derived from the hydrolysis of …
of the genome in the context of chromatin by using energy derived from the hydrolysis of …
Targeting histone deacetylases in diseases: where are we?
Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …
human pathologies, in particular cancer. Histone acetylation balance obtained through …
The increasing roles of epigenetics in breast cancer: Implications for pathogenicity, biomarkers, prevention and treatment
C Basse, M Arock - International journal of cancer, 2015 - Wiley Online Library
Nowadays, the mechanisms governing the occurrence of cancer are thought to be the
consequence not only of genetic defects but also of epigenetic modifications. Therefore …
consequence not only of genetic defects but also of epigenetic modifications. Therefore …
[PDF][PDF] Zic2 is an enhancer-binding factor required for embryonic stem cell specification
Z Luo, X Gao, C Lin, ER Smith, SA Marshall… - Molecular cell, 2015 - cell.com
The Zinc-finger protein of the cerebellum 2 (Zic2) is one of the vertebrate homologs of the
Drosophila pair-rule gene odd-paired (opa). Our molecular and biochemical studies …
Drosophila pair-rule gene odd-paired (opa). Our molecular and biochemical studies …
[HTML][HTML] Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders
It is becoming increasingly important to understand how epigenetic mechanisms control
gene expression during neurodevelopment. Two epigenetic mechanisms that have received …
gene expression during neurodevelopment. Two epigenetic mechanisms that have received …
The expanding epigenetic landscape of non-model organisms
R Bonasio - Journal of Experimental Biology, 2015 - journals.biologists.com
Epigenetics studies the emergence of different phenotypes from a single genotype. Although
these processes are essential to cellular differentiation and transcriptional memory, they are …
these processes are essential to cellular differentiation and transcriptional memory, they are …
Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting
Recent proteomic studies have identified a novel histone deacetylase complex that is
upregulated during mitosis and is associated with cyclin A. This complex is conserved from …
upregulated during mitosis and is associated with cyclin A. This complex is conserved from …