The immunogenetics of multiple sclerosis: A comprehensive review

JA Hollenbach, JR Oksenberg - Journal of autoimmunity, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …

Multiple sclerosis relapses: epidemiology, outcomes and management. A systematic review

T Kalincik - Neuroepidemiology, 2015 - karger.com
Relapses (episodic exacerbations of neurological signs or symptoms) are a defining feature
of relapsing-remitting multiple sclerosis (MS), the most prevalent MS phenotype. While their …

Class II HLA interactions modulate genetic risk for multiple sclerosis

Nature genetics, 2015 - nature.com
Association studies have greatly refined the understanding of how variation within the
human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the …

Genetic determinants of risk and progression in multiple sclerosis

A Didonna, JR Oksenberg - Clinica chimica acta, 2015 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease that represents a primary cause of
neurological disability in the young adult population. Converging evidence supports the …

Higher weight in adolescence and young adulthood is associated with an earlier age at multiple sclerosis onset

KS Kavak, BE Teter, J Hagemeier… - Multiple Sclerosis …, 2015 - journals.sagepub.com
Background: Growing evidence suggests an association between adolescent obesity and
increased risk of multiple sclerosis (MS). Objective: The objective of this paper is to …

The influence of HLA‐DRB1*15 on motor cortical pathology in multiple sclerosis

RL Yates, MM Esiri, J Palace, A Mittal… - Neuropathology and …, 2015 - Wiley Online Library
Aim Multiple sclerosis (MS) is a common and heterogeneous CNS inflammatory
demyelinating disease. The HLA‐DRB1 locus may influence clinical outcome. MS cortical …

The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population

J Michalik, D Čierny, E Kantorová… - Neurological …, 2015 - Taylor & Francis
Objective: The aim of the present study was to assess the association between HLA-DRB1
and-DQB1 allele groups with the genetic predisposition to multiple sclerosis (MS) in the …

[HTML][HTML] Association of CD58 polymorphism with multiple sclerosis and response to interferon ß therapy in a subset of Iranian population

S Torbati, F Karami, M Ghaffarpour… - Cell Journal (Yakhteh …, 2015 - ncbi.nlm.nih.gov
Objective Multiple sclerosis (MS) is one of the leading neurodegenerative causes of physical
disability world-wide. Genetic aberrations of autoimmunity pathway components have been …

The role of HLA in MS susceptibility and phenotype

JM Greer - Emerging and Evolving Topics in Multiple Sclerosis …, 2015 - Springer
One of the most consistent findings in multiple sclerosis (MS) is that development of MS is
linked with carriage of the class II human leucocyte antigen (HLA) molecule HLA-DRB1* 15 …

[PDF][PDF] Therapeutic effects of adipose derived mesenchymal stem cells on remyelination process in inflammatory demyelinating diseases

N Ghasemi - channels, 2015 - researchgate.net
Multiple sclerosis “MS” is a frequent demyelinating disease that affecting the central nervous
system and associated with a progressive clinical course or severe disability in young …