Glioma

M Weller, W Wick, K Aldape, M Brada… - Nature reviews Disease …, 2015 - nature.com
Gliomas are primary brain tumours that are thought to derive from neuroglial stem or
progenitor cells. On the basis of their histological appearance, they have been traditionally …

The role of surgery in the management of patients with diffuse low grade glioma: a systematic review and evidence-based clinical practice guideline

MK Aghi, BV Nahed, AE Sloan, TC Ryken… - Journal of neuro …, 2015 - Springer
Question Should patients with imaging suggestive of low grade glioma (LGG) undergo
observation versus treatment involving a surgical procedure? Target population These …

Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period

SL Hervey-Jumper, J Li, D Lau, AM Molinaro… - Journal of …, 2015 - thejns.org
OBJECT Awake craniotomy is currently a useful surgical approach to help identify and
preserve functional areas during cortical and subcortical tumor resections. Methodologies …

Localizing seizure-susceptible brain regions associated with low-grade gliomas using voxel-based lesion-symptom mapping

Y Wang, T Qian, G You, X Peng, C Chen, Y You… - Neuro …, 2015 - academic.oup.com
Background Patients afflicted with low-grade glioma (LGG) frequently suffer from seizures.
The mechanisms of seizure initiation in these patients remain poorly understood. Tumor …

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor‐associated epilepsy

SL Campbell, S Robel, VA Cuddapah, S Robert… - Glia, 2015 - Wiley Online Library
Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy.
Previous work revealed the importance of tumor‐derived excitatory glutamate (Glu) release …

Neurocognitive function in newly diagnosed low-grade glioma patients undergoing surgical resection with awake mapping techniques

CA Racine, J Li, AM Molinaro, N Butowski… - Neurosurgery, 2015 - journals.lww.com
BACKGROUND: Low-grade glioma (LGG) patients have increased life expectancy, so
interest is high in the treatments that maximize cognition and quality of life. OBJECTIVE: To …

Seizure outcome after radiotherapy and chemotherapy in low-grade glioma patients: a systematic review

JAF Koekkoek, M Kerkhof, L Dirven… - Neuro …, 2015 - academic.oup.com
There is growing evidence that antitumor treatment contributes to better seizure control in
low-grade glioma patients. We performed a systematic review of the current literature on …

IDH1/2 mutation is associated with seizure as an initial symptom in low-grade glioma: a report of 311 Chinese adult glioma patients

Z Zhong, Z Wang, Y Wang, G You, T Jiang - Epilepsy research, 2015 - Elsevier
Background Seizure commonly presents as an initial symptom and plays an important role
in the clinical presentation and quality of life of patients with low-grade glioma (LGG). To …

Seizure reduction in a low-grade glioma: more than a beneficial side effect of temozolomide

JAF Koekkoek, L Dirven, JJ Heimans… - Journal of Neurology …, 2015 - jnnp.bmj.com
Background Seizures are a common symptom in patients with low-grade glioma (LGG),
negatively influencing quality of life, if uncontrolled. Besides antiepileptic drugs, antitumour …

Is there a risk of seizures in “preventive” awake surgery for incidental diffuse low-grade gliomas?

GL de Oliveira Lima, H Duffau - Journal of neurosurgery, 2015 - thejns.org
OBJECT Although a large amount of data supports resection for symptomatic diffuse low-
grade glioma (LGG), the therapeutic strategy regarding incidental LGG (ILGG) is still a matter …