Background. Metabolism in the tumor microenvironment can play a critical role in
tumorigenesis and tumor aggression. Metabolic coupling may occur between tumor …

Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-
related complications. Bone pain is one of the most common complications associated with …

Here, we developed an isogenic cell model of “stemness” to facilitate protein biomarker
discovery in breast cancer. For this purpose, we used knowledge gained previously from the …

Clear cell renal cell carcinomas (ccRCCs) have inactivation of the von Hippel–Lindau
protein, leading to the accumulation of hypoxia-inducible factor-α (HIF-α). HIF-1α induces …

Abstract Purpose Monocarboxylate transporter 4 (MCT4) is a critical component in the
glycolytic metabolism of cancer cells, and is also important for malignant behavior. We …

The aim of the work was to evaluate whether or not there is glycolytic reprogramming in the
neighboring cells of colorectal cancer (CRC). Using postoperative material we have …

Human head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
type worldwide, possibly due to the significant role of alcohol and tobacco use in its …

Growing by an alarming rate in the Western world, obesity has become a condition
associated with a multitude of diseases such as diabetes, metabolic syndrome and various …

Anaplastic thyroid cancer (ATC) is one of the most aggressive human cancers. Key signal
transduction pathways that regulate mitochondrial metabolism are frequently altered in ATC …

Background Head and neck squamous cell carcinoma (HNSCC) is a cancer that is
characterized by its high morbidity and mortality rates. While tobacco use and alcohol …