[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
Prognostic indications of elevated MCT4 and CD147 across cancer types: a meta‐analysis
CD Bovenzi, J Hamilton, P Tassone… - BioMed research …, 2015 - Wiley Online Library
Background. Metabolism in the tumor microenvironment can play a critical role in
tumorigenesis and tumor aggression. Metabolic coupling may occur between tumor …
tumorigenesis and tumor aggression. Metabolic coupling may occur between tumor …
[HTML][HTML] Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells
The mevalonate pathway provides metabolites for post-translational modifications such as
farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently …
farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently …
Stromal fibroblast in age-related cancer: role in tumorigenesis and potential as novel therapeutic target
A Elkhattouti, M Hassan, CR Gomez - Frontiers in oncology, 2015 - frontiersin.org
Incidence of most common cancers increases with age due to accumulation of damage to
cells and tissues. Stroma, the structure close to the basement membrane, is gaining …
cells and tissues. Stroma, the structure close to the basement membrane, is gaining …
[HTML][HTML] Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer
XJ Shen, H Zhang, GS Tang, XD Wang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
Stromal fibroblasts play an important role in chronic cancer-related inflammation and the
development as well as progression of malignant diseases. However, the difference and …
development as well as progression of malignant diseases. However, the difference and …
[HTML][HTML] Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts
Cancer cells grow in highly complex stromal microenvironments, which through metabolic
remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate …
remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate …
[PDF][PDF] Can Spirulina maxima reduce the mutagenic potential of sibutramine?
The worldwide obesity pandemic requires the use of antiobesity drugs. Sibutramine is an
anti-obesity drug that has been used worldwide but is indiscriminately consumed in Brazil …
anti-obesity drug that has been used worldwide but is indiscriminately consumed in Brazil …
肿瘤代谢共生的研究进展
杨琼， 夏良平 - 临床肿瘤学杂志, 2015 - manu65.magtech.com.cn
20 世纪20 年代, 德国生化学家瓦伯格发现即使在有氧条件下, 肿瘤细胞也是通过糖酵解的方式
获得生存必需的能量, 这一现象被称为瓦伯格效应. 然而, 后续越来越多的研究发现并非所有的 …
获得生存必需的能量, 这一现象被称为瓦伯格效应. 然而, 后续越来越多的研究发现并非所有的 …