Bone marrow (BM) morphologic features remain the cornerstone of diagnosis in both
essential thrombocythemia (ET) and polycythemia vera (PV). In addition, recently discovered …

Myeloproliferative neoplasms (MPNs) are a group of clonal hematopoietic stem cell
disorders characterized by aberrant proliferation of one or more myeloid lineages often with …

The first-in-class JAK1/JAK2 inhibitor ruxolitinib inhibits JAK/STAT signaling, inducing
durable reductions in splenomegaly and constitutional symptoms in patients with …

BMS-911543 is a complex pyrrolopyridine investigated as a potential treatment for
myeloproliferative disorders. The development of a short and efficient synthesis of this …

The approach to the diagnosis and management of essential thrombocythaemia (ET) is
steadily changing, influenced by advances in molecular biology, data from clinical trials and …

The diagnosis and management of hematologic malignancy during pregnancy is a
significant challenge. This is due to both medical and ethical considerations regarding when …

Purpose Myelofibrosis is a haematopoietic stem cell neoplasm characterized by bone
marrow inflammation, reactive marrow fibrosis and extramedullary haematopoiesis. The aim …

Hematopoietic stem cell transplantation (HCT) is currently the only curative treatment for
myelofibrosis (MF), but this option is complicated by high incidences of associated morbidity …

Цель. Обзор литературы с освещением вопросов эпидемиологии, терминологии,
этиологии, механизмов становления и развития эссенциальной тромбоцитемии, а …

Introduction: Myelofibrosis (MF) is a clonal haematological disease associated with recurrent
somatic gene mutations (JAK2 V617F, MPL, CALR) and constitutive activation of the Janus …