Nucleic acid aptamers in cancer research, diagnosis and therapy
Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …
Single‐stranded DNA aptamers against pathogens and toxins: identification and biosensing applications
Molecular recognition elements (MREs) can be short sequences of single‐stranded DNA,
RNA, small peptides, or antibody fragments. They can bind to user‐defined targets with high …
RNA, small peptides, or antibody fragments. They can bind to user‐defined targets with high …
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy
Currently, major concerns about the safety and efficacy of RNA interference (RNAi)-based
bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery …
bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery …
[HTML][HTML] Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity
The CC chemokine receptor type 5 (CCR5) is a receptor expressed by T cells and
macrophages that serves as a coreceptor for macrophage-tropic HIV-1. Loss of CCR5 is …
macrophages that serves as a coreceptor for macrophage-tropic HIV-1. Loss of CCR5 is …
Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy
HM Meng, T Fu, XB Zhang, W Tan - National Science Review, 2015 - academic.oup.com
Nucleic acid aptamers, which are generated by a novel technique called SELEX (systematic
evolution of ligands by exponential enrichment), have recently attracted significant attention …
evolution of ligands by exponential enrichment), have recently attracted significant attention …
Aptamers overview: selection, features and applications
LI Hernandez, I Machado, T Schafer… - Current topics in …, 2015 - ingentaconnect.com
Apatamer technology has been around for a quarter of a century and the field had matured
enough to start seeing real applications, especially in the medical field. Since their …
enough to start seeing real applications, especially in the medical field. Since their …
Aptamer biosensor for selective and rapid determination of insulin
SM Taghdisi, NM Danesh, P Lavaee… - Analytical …, 2015 - Taylor & Francis
Insulin plays an important role in glucose metabolism and its detection in biological fluids is
of interest. In this study, a triple-helix molecular switch was employed for the simple …
of interest. In this study, a triple-helix molecular switch was employed for the simple …
Aptamer–siRNA chimeras for HIV
M Takahashi, JC Burnett, JJ Rossi - Gene Therapy for HIV and Chronic …, 2015 - Springer
Since 1980s, HIV/AIDS has escalated into a global pandemic. Although combinatorial
antiretroviral therapy (cART) regimens can suppress plasma virus levels to below the …
antiretroviral therapy (cART) regimens can suppress plasma virus levels to below the …
Targeting cancer cells using aptamers: Cell-SELEX approach and recent advancements
J Barman - RSC Advances, 2015 - pubs.rsc.org
Aptamers are short single stranded nucleic acid molecules, isolated from a pool of nucleic
acid molecules by the method called SELEX (Systematic Evolution of Ligands by …
acid molecules by the method called SELEX (Systematic Evolution of Ligands by …
Comparison of the methods for generating single-stranded DNA in SELEX
C Liang, D Li, G Zhang, H Li, N Shao, Z Liang, L Zhang… - Analyst, 2015 - pubs.rsc.org
The generation of single-stranded DNA (ssDNA) from double-stranded PCR products is an
essential step in the selection of aptamers by systematic evolution of ligands by exponential …
essential step in the selection of aptamers by systematic evolution of ligands by exponential …