The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SV s) at
specialized regions of the presynaptic membrane called active zones (AZ s). These regions …

The sensory epithelium of the mammalian inner ear contains two types of mechanosensory
cells: inner (IHC) and outer hair cells (OHC). They both transduce mechanical force …

A major challenge in neuroscience is to determine the nanoscale position and quantity of
signaling molecules in a cell type–and subcellular compartment–specific manner. We …

In the mammalian cochlea, sound is encoded at synapses between inner hair cells (IHCs)
and type I spiral ganglion neurons (SGNs). Each SGN receives input from a single IHC …

All acoustic information from the periphery is encoded in the timing and rates of spikes in the
population of spiral ganglion neurons projecting to the central auditory system …

EF-hand Ca2+-binding proteins are thought to shape the spatiotemporal properties of
cellular Ca2+ signaling and are prominently expressed in sensory hair cells in the ear. Here …

Here we define activities of RIM-binding protein (RBP) that are essential for baseline
neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a∼ …

Active zones (AZ s) of inner hair cells (IHC s) indefatigably release hundreds of vesicles per
second, requiring each release site to reload vesicles at tens per second. Here, we report …

Ca2+ influx triggers the fusion of synaptic vesicles at the presynaptic active zone (AZ). Here
we demonstrate a role of Ras-related in brain 3 (Rab3)–interacting molecules 2α and β …

Ribbon synapses of cochlear inner hair cells (IHCs) employ efficient vesicle replenishment
to indefatigably encode sound. In neurons, neuroendocrine and immune cells, vesicle …