Metabolic reprogramming of the heart through stearoyl-CoA desaturase
Abstract Stearoyl-CoA desaturase (SCD), a central enzyme in lipid metabolism that
synthesizes monounsaturated fatty acids, has been linked to tissue metabolism and body …
synthesizes monounsaturated fatty acids, has been linked to tissue metabolism and body …
[HTML][HTML] A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated …
Y Guo, W Yu, D Sun, J Wang, C Li, R Zhang… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Mitochondrial aldehyde dehydrogenase (ALDH2) is known to offer myocardial protection
against stress conditions including ischemia-reperfusion injury, alcoholism and diabetes …
against stress conditions including ischemia-reperfusion injury, alcoholism and diabetes …
Macrophage migration inhibitory factor (MIF) knockout preserves cardiac homeostasis through alleviating Akt-mediated myocardial autophagy suppression in high-fat …
X Xu, J Ren - International journal of obesity, 2015 - nature.com
Background: Macrophage migration inhibitory factor (MIF) has a role in the development of
obesity and diabetes. However, whether MIF has a role in fat diet-induced obesity and …
obesity and diabetes. However, whether MIF has a role in fat diet-induced obesity and …
[HTML][HTML] Deletion of protein tyrosine phosphatase 1B rescues against myocardial anomalies in high fat diet-induced obesity: Role of AMPK-dependent autophagy
Obesity-induced cardiomyopathy may be mediated by alterations in multiple signaling
cascades involved in glucose and lipid metabolism. Protein tyrosine phosphatase-1B …
cascades involved in glucose and lipid metabolism. Protein tyrosine phosphatase-1B …
Obesity and metabolomics: metallothioneins protect against high-fat diet-induced consequences in metallothionein knockout mice
Obesity continues to rise as an alarming global epidemic. System level mechanisms,
diagnostics, and therapeutics are sorely needed so as to identify at risk individuals and …
diagnostics, and therapeutics are sorely needed so as to identify at risk individuals and …
[HTML][HTML] Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/PGC-1a/Akt signalling
Abstract High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and
cardiovascular disease. In this research 6 week old male hamsters (n= 10) fed with HFD …
cardiovascular disease. In this research 6 week old male hamsters (n= 10) fed with HFD …
Antioxidant metallothionein alleviates endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction
L Yang, J Wang, J Yang, R Schamber, N Hu… - Free Radical …, 2015 - Taylor & Francis
Aims. Endoplasmic reticulum (ER) stress exerts myocardial oxidative stress, apoptosis, and
contractile anomalies, although the precise interplay between ER stress and apoptosis …
contractile anomalies, although the precise interplay between ER stress and apoptosis …
[HTML][HTML] Left ventricular mechanical dysfunction in diet-induced obese mice is exacerbated during inotropic stress: a cine DENSE cardiovascular magnetic resonance …
CM Haggerty, AC Mattingly, SP Kramer… - Journal of …, 2015 - Elsevier
Background Obesity is a risk factor for cardiovascular disease. There is evidence of impaired
left ventricular (LV) function associated with obesity, which may relate to cardiovascular …
left ventricular (LV) function associated with obesity, which may relate to cardiovascular …
Mitochondrial dysfunction and oxidative stress in metabolic heart disease
A Elezaby - 2015 - search.proquest.com
Patients with obesity develop a metabolic heart disease (MHD) of unclear mechanisms and
limited therapeutic options. MHD is characterized by left-ventricular hypertrophy and …
limited therapeutic options. MHD is characterized by left-ventricular hypertrophy and …