A series of thirty (30) thiazole analogs were prepared, characterized by 1 H NMR, 13 C NMR
and EI-MS and evaluated for Acetylcholinesterase and butyrylcholinesterase inhibitory …

This work reports the in vitro antioxidant and inhibitory activities of hexane, methanol and
water extracts of cork oak (Quercus suber) against acetylcholinesterase (AChE) …

Abstract Development of Multi-Target Directed Ligands (MTDLs) has emerged as a
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …

A series of benzofuran-based N-benzylpyridinium derivatives 5a–o were designed and
synthesized as novel AChE inhibitors. The synthetic pathway of the compounds involved the …

Brain oxidative stress due to chronic cerebral hypoperfusion was considered to be the major
risk factor in the pathogenesis of vascular dementia. In this study, we investigated the …

The present study investigated the toxic effects of individual, combined (binary and ternary)
exposure to lead, arsenic and mercury on,(i) oxidative stress (ii) alterations in brain biogenic …

This study investigated the phenolic content, enzyme-inhibitory and antioxidant activities of
ethyl acetate, methanol and water extracts of Phlomis armeniaca. HPLC analysis showed …

Abstract Background/Aims: Factors including rate of disease progression, different aspects
of cholinesterase inhibitor (ChEI) treatment, and use of community-based services might …

In this present study some benzothiazole derivatives bearing piperazine and thiocarbamate
moieties were synthesized and their potential anticholinesterase properties were …

Amyloid beta (Aβ) and cholinesterase enzymes (AChE, BuChE) are important biological
targets for the effective treatment of Alzheimer's disease. In this study, the aim was to …