Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …

Abstract Background: The number of Mendelian randomization analyses including large
numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Finding individual-level data for adequately-powered Mendelian randomization analyses
may be problematic. As publicly-available summarized data on genetic associations with …

Both polygenicity (many small genetic effects) and confounding biases, such as cryptic
relatedness and population stratification, can yield an inflated distribution of test statistics in …

Linear mixed models are a powerful statistical tool for identifying genetic associations and
avoiding confounding. However, existing methods are computationally intractable in large …

A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci,
typically weighted by effect sizes estimated from a genome-wide association study. The …

Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an
outcome by using genetic variants as instrumental variables, but its validity relies on the …