The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where
The characteristic feature of healthy living organisms is the preservation of homeostasis.
Compelling evidence highlight that the DNA damage response and repair (DDR/R) and …
Compelling evidence highlight that the DNA damage response and repair (DDR/R) and …
IAPs, regulators of innate immunity and inflammation
Y Estornes, MJM Bertrand - Seminars in cell & developmental biology, 2015 - Elsevier
As indicated by their name, members of the Inhibitor of APoptosis (IAP) family were first
believed to be functionally restricted to apoptosis inhibition. It is now clear that IAPs have a …
believed to be functionally restricted to apoptosis inhibition. It is now clear that IAPs have a …
A gut-vascular barrier controls the systemic dissemination of bacteria
In healthy individuals, the intestinal microbiota cannot access the liver, spleen, or other
peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can …
peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can …
Nlrp6 regulates intestinal antiviral innate immunity
The nucleotide-binding oligomerization domain–like receptor (Nlrp) 6 maintains gut
microbiota homeostasis and regulates antibacterial immunity. We now report a role for Nlrp6 …
microbiota homeostasis and regulates antibacterial immunity. We now report a role for Nlrp6 …
[HTML][HTML] Progranulin protects against renal ischemia/reperfusion injury in mice
Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is
widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory …
widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory …
Structure-based design of human TLR8-specific agonists with augmented potency and adjuvanticity
M Beesu, G Caruso, ACD Salyer… - Journal of medicinal …, 2015 - ACS Publications
Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and
monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine …
monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine …
The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)
X Meng, X Tian, G Nie, J Wang, M Liu, K Jiang… - Fish & Shellfish …, 2015 - Elsevier
The present study was conducted to elucidate the effects of copper exposure on the immune
system and lipid metabolism of the Japanese scallop, Mizuhopecten yessoensis …
system and lipid metabolism of the Japanese scallop, Mizuhopecten yessoensis …
[HTML][HTML] NLR family pyrin domain containing 3 (NLRP3) inflammasome gene polymorphism rs7512998 (C> T) predicts aging-related increase of blood pressure, the …
T Kunnas, K Määttä, ST Nikkari - Immunity & Ageing, 2015 - Springer
Background The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome
by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms …
by cellular stress leads to activation of the inflammasome, and NLRP3 gene polymorphisms …
Structural and functional insights into CARDs of zebrafish (Danio rerio) NOD1 and NOD2, and their interaction with adaptor protein RIP2
Nucleotide-binding and oligomerization domain-containing protein 1 (NOD1) and NOD2 are
cytosolic pattern-recognition receptors (PRRs) composed of an N-terminal caspase …
cytosolic pattern-recognition receptors (PRRs) composed of an N-terminal caspase …
Intrinsic flexibility of NLRP pyrin domains is a key factor in their conformational dynamics, fold stability, and dimerization
Nucleotide‐binding domain leucine‐rich repeat‐containing receptors (NLRs) are key
proteins in the innate immune system. The 14 members of the NLRP family of NLRs contain …
proteins in the innate immune system. The 14 members of the NLRP family of NLRs contain …