Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal
adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of …

The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …

Covering: 2000 to 2014 Cancer is one of the leading causes of death worldwide. Ginseng, a
key ingredient in traditional Chinese medicine, shows great promise as a new treatment …

The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of
which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the …

Hypoxia is a feature of all solid tumors, contributing to tumor progression and therapy
resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia …

Endothelial function is largely dictated by its ability to rapidly sense environmental cues and
adapt to these stimuli through changes in vascular tone, inflammation/immune recruitment …

Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell
division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human …

Delayed revascularization of ischemic neural tissue is a major impediment to preservation of
function in central nervous system (CNS) diseases including stroke and ischemic …