Although robust and highly effective anti-viral T cells contribute to the clearance of many
acute infections, viral persistence is associated with the development of functionally inferior …

Yellow fever, a mosquito-borne flavivirus disease occurs in tropical areas of South America
and Africa. It is a disease of major historical importance, but remains a threat to travelers to …

CD8+ T cells contribute to the control of HIV, but it is not clear whether initial immune
responses modulate the viral set point. We screened high-risk uninfected women twice a …

Four Ebola patients received care at Emory University Hospital, presenting a unique
opportunity to examine the cellular immune responses during acute Ebola virus infection …

Host-and pathogen-specific factors interplay with the environment in a complex fashion to
determine the outcome of infection with Mycobacterium tuberculosis (Mtb), resulting in one …

Efficient and persisting immune memory is essential for long-term protection from infectious
and malignant diseases. The yellow fever (YF) vaccine is a live attenuated virus that …

Intensified efforts to promote protective T cell-based immunity in vaccines and
immunotherapies have created a compelling need to expand our understanding of human T …

ABSTRACT A detailed characterization of the dynamics and breadth of the immune
response to an acute viral infection, as well as the determinants of recruitment to …

Oncolytic viruses are a relatively new class of anti-cancer immunotherapy agents. Several
viruses have undergone evaluation in clinical trials in the last decades, and the first agent is …

CD8 T cells are a potent tool for eliminating intracellular pathogens and tumor cells. Thus,
eliciting robust CD8 T-cell immunity is the basis for many vaccines under development …