The equine aging process involves many changes to the immune system that may be
related to genetics, the level of nutrition, the environment and/or an underlying subclinical …

Each year, approximately 1 in 9 infants in the United States, more than 440,000 infants
yearly, are born prematurely (< 37 weeks gestation). 1 These infants suffer from …

Background. Telomeres provide a key mechanism for protecting the integrity of
chromosomes and their attrition after cell division and during aging are evident in …

Background Although influenza causes significant morbidity and mortality in the elderly, the
factors underlying the reduced vaccine immunogenicity and efficacy in this age group are …

Aging has been associated with increased generation of free radicals as well as
immunosenescence. Previous studies have identified older individuals with inverted T CD4 …

Measuring changes of the T cell receptor (TCR) repertoire is important to many fields of
medicine. Flow cytometry is a popular technique to study the TCR repertoire, as it quickly …

Patients with glioblastoma multiforme (GBM) are immunosuppressed and have a broad
range of immunological defects in both innate and adaptive immune responses. GBMs are …

Viral infections, including cytomegalovirus (CMV), abrogate transplantation tolerance in
animal models. Whether this also occurs in humans remains elusive. We investigated how …

Insight into the maintenance of naive T cells is essential to understand defective immune
responses in the context of aging and other immune compromised states. In humans, naive …

Background Despite successful treatment and CD4+ T-cell recovery, HIV-infected
individuals often experience a profound immune dysregulation characterized by a …