Due to differences in anatomy, primary rectal and colon cancer require different staging
procedures, different neo-adjuvant treatment and different surgical approaches. For …

Poor histological differentiation is currently considered among the adverse histopathological
factors associated with unfavourable clinical course of colorectal carcinoma (CRC). At …

Background Somatic mutations have the potential to encode “non-self” immunogenic
antigens. We hypothesized that tumors with a large number of somatic mutations due to …

Background: The objective of the study was to examine the role of microsatellite instability
(MSI) and BRAF V600E mutation in colorectal cancer (CRC) by categorising patients into …

The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …

The increasing interest of the oncology community in tumour classification and prediction of
outcome to targeted therapies has put emphasis on an improved identification of tumour …

Screening for DNA mismatch repair (MMR) deficiency in colorectal and endometrial
carcinomas identifies patients at risk for Lynch syndrome. Some patients with MMR-deficient …

Mismatch repair defective (MMRd) colorectal carcinoma (CRC) is a distinct molecular
phenotype of colorectal cancer, including 12% of sporadic CRC and 3% of Lynch Syndrome …

Current guidelines on germline mutation testing for patients suspected of having Lynch
syndrome are not entirely clear in patients with tumors demonstrating isolated loss of PMS2 …

Although often viewed as a single disease, colorectal cancer more accurately represents a
constellation of heterogeneous subtypes that result from different combinations of genetic …