Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …

DNA methylation plays a significant role in gastric carcinogenesis. The CpG island
methylator phenotype (CIMP) characterizes distinct subtypes of gastric cancer (GC) and the …

Several studies have recently identified strong epigenetic signals related to tobacco
smoking. However, an aspect that did not receive much attention is the evolution of …

An increasing number of studies have proposed a strong correlation between reactive
oxygen species (ROS)‐induced oxidative stress (OS) and the pathogenesis of Alzheimer's …

In eusocial insects, genetically identical individuals can exhibit striking differences in
behavior and longevity. The molecular basis of such phenotypic plasticity is of great interest …

Vascular smooth muscle cells (SMCs), like all cells, acquire a cell-specific epigenetic
signature during development that includes acquisition of a unique repertoire of histone and …

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in
repressive histone post-translational modifications. However, the chromatin marks …

The sixth DNA base 5-hydroxymethylcytosine (5hmC) is the major oxidation product of the
epigenetic modification 5-methylcytosine (5mC), mediating DNA demethylation in mammals …

Early embryonic loss and altered gene expression in in vitro produced blastocysts are
believed to be partly caused by aberrant DNA methylation. However, specific embryonic …

Short interspersed nuclear elements (SINEs), such as Alu, spread by retrotransposition,
which requires their transcripts to be copied into DNA and then inserted into new …