Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Plasma membrane repair is a conserved cellular response mediating active resealing of
membrane disruptions to maintain homeostasis and prevent cell death and progression of …

Dysfunction of caveolae is involved in human muscle disease, although the underlying
molecular mechanisms remain unclear. In this paper, we have functionally characterized …

Injury to the renal proximal tubular epithelium (PTE) represents the underlying consequence
of acute kidney injury (AKI) after exposure to various stressors, including nephrotoxins and …

Ischemic heart disease is a leading cause of death in human population and protection of
myocardial infarction (MI) associated with ischemia–reperfusion (I/R) remains a challenge …

Caveolae are specialized small plasma-membrane invaginations that play crucial cellular
functions. Two essential protein families are required for caveola formation: membrane …

Metabolic syndrome is a cluster of risk factors, such as obesity, insulin resistance, and
hyperlipidemia that increases the individual's likelihood of developing cardiovascular …

Zinc is an essential trace element that participates in a wide range of biological functions,
including wound healing. Although Zn 2+ deficiency has been linked to compromised …

Rhabdomyosarcoma (RMS) is a childhood soft tissue tumor with broad expression of
markers that are typically found in skeletal muscle. Cavin-1 is a recently discovered protein …

Considerable research supports a model in which hydrolytic enzymes of mammalian
lysosomes are sorted to their destinations in a receptor-dependent mechanism. The ligand …