The response to exercise training (trainability) has been shown to have a strong heritable
component. There is growing evidence suggesting that traits such as trainability do not only …

Epigenetic mechanisms are emerging as mediators linking early environmental exposures
during pregnancy with programmed changes in gene expression that alter offspring growth …

Neuronal diversity is essential for mammalian brain function but poses a challenge to
molecular profiling. To address the need for tools that facilitate cell-type-specific epigenomic …

The developing mammalian brain is destined for a female phenotype unless exposed to
gonadal hormones during a perinatal sensitive period. It has been assumed that the …

Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …

DNA methylation is an epigenetic mark thought to be robust to environmental perturbations
on a short time scale. Here, we challenge that view by demonstrating that the infection of …

Contrary to the long-held belief that DNA methylation of terminally differentiated cells is
permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA …

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the
first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients …

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …

Ten-eleven translocation (TET) enzymes mediate the conversion of 5-methylcytosine (5mC)
to 5-hydroxymethylcytosine (5hmC), which is enriched in brain, and its ultimate DNA …