It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

Prostate cancer is a leading cause of cancer death amongst males. The main clinical
dilemma in treating prostate cancer is the high number of indolent cases that confer a …

TRPM8 is a cold sensor that is highly expressed in the prostate as well as in other non-
temperature-sensing organs, and is regulated by downstream receptor–activated signaling …

Testosterone is a key steroid hormone in the development of male reproductive tissues and
the regulation of the central nervous system. The rapid signaling mechanism induced by …

The transient receptor potential ion channel of the melastatin subfamily, TRPM8, is a major
cold receptor in the peripheral nervous system. Along with the sensory neurons, the TRPM8 …

The cold and menthol receptor TRPM8 is highly expressed in prostate and prostate cancer
(PC). Recently, we identified that TRPM8 is as an ionotropic testosterone receptor. The …

Reference treatment of advanced prostate cancer (PCa) relies on pharmacological or
surgical androgen deprivation therapy. However, it is only temporarily efficient as tumor cells …

Background Hepatocellular carcinoma (HCC) is a multi-factor, multi-step, multi-gene and
complicated process resulting from the accumulation of sequential genetic and epigenetic …

Transient receptor potential (TRP) channels play an important role in many fundamental
cellular processes and are also implicated in initiation and progression of different cancers …

En los últimos años, se ha sugerido que en el desarrollo del cáncer se produce un
remodelado de la señal de Ca2+, sin embargo, no están claros cuáles son los mecanismos …