MicroRNAs (miRNAs) direct post-transcriptional regulation of human genes by guiding
Argonaute proteins to complementary sites in messenger RNAs (mRNAs) targeted for …

The patterning function of Hox proteins relies on assembling protein complexes with PBC
proteins, which often involves a protein motif found in most Hox proteins, the so-called …

Rolling circle amplification (RCA) has been considered as a powerful tool for nucleic acids
detection. Here, a novel repressor-RCA-based method for l-tryptophan (l-Trp) detection was …

The growing number of high-quality experimental (X-ray, NMR) structures of protein–DNA
complexes has sufficient enough information to assess whether universal rules governing …

Using terahertz time-domain spectroscopy (THz-TDS), the frequency-dependent dielectric
constant of deoxyribonucleic acid (DNA) in solution was measured. The response of the …

Transcriptional regulation has been studied intensively in recent decades. One important
aspect of this regulation is the interaction between regulatory proteins, such as transcription …

In archaea, packaging of DNA into chromatin and transcriptional regulation are closely
related processes and the proteins involved therein often exhibit overlapping roles. In case …

E. coli protein tryptophan repressor (TrpR) regulates expression of tryptophan biosynthetic
genes in response to the intracellular concentration of L-tryptophan (L-trp). The binding of L …

Gene expression is regulated on many levels of which transcription regulation is the most
studied. Transcription factors (TF) arguably are the most integral part of transcriptional …

This thesis concerns the use of dimeric coiled-coil peptides as components for synthetic
protein motors. Studies of the hub structures of two motor designs are described. Firstly, I …