Risk algorithm using serial biomarker measurements doubles the number of screen-detected cancers compared with a single-threshold rule in the United Kingdom …

U Menon, A Ryan, J Kalsi, A Gentry-Maharaj… - Journal of Clinical …, 2015 - ascopubs.org
Purpose Cancer screening strategies have commonly adopted single-biomarker thresholds
to identify abnormality. We investigated the impact of serial biomarker change interpreted …

Use of biomarkers in screening for cancer

MJ Duffy - Advances in Cancer Biomarkers: From biochemistry to …, 2015 - Springer
Screening for premalignant lesions or early invasive disease has the potential to reduce
mortality from cancer. Because of their ease of measurement, several biomarkers have been …

Costs and benefits of opportunistic salpingectomy as an ovarian cancer prevention strategy

JS Kwon, JN McAlpine, GE Hanley… - Obstetrics & …, 2015 - journals.lww.com
OBJECTIVE: To conduct a cost-effectiveness analysis of opportunistic salpingectomy
(elective salpingectomy at hysterectomy or instead of tubal ligation). METHODS: A Markov …

microRNA and ovarian cancer

R Langhe - microRNA: Cancer: From Molecular Biology to Clinical …, 2015 - Springer
Ovarian cancer is the fifth most common cancer in women and the leading cause of death
from gynaecological malignancy in the Western world. The majority of ovarian cancers are …

[HTML][HTML] Validation of LRG1 as a potential biomarker for detection of epithelial ovarian cancer by a blinded study

J Wu, H Yin, J Zhu, RJ Buckanovich, JD Thorpe, J Dai… - PloS one, 2015 - journals.plos.org
Background Leucine-rich alpha-2-glycoprotein (LRG1) was found to be differentially
expressed in sera from patients with Epithelial Ovarian Cancer (EOC). The aim of this study …

The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity

KE Chang, BR Wei, JP Madigan, MD Hall… - Molecular cancer …, 2015 - AACR
Despite early positive response to platinum-based chemotherapy, the majority of ovarian
carcinomas develop resistance and progress to fatal disease. Protein phosphatase 2A …

Serial patterns of ovarian cancer biomarkers in a prediagnosis longitudinal dataset

O Blyuss, A Gentry-Maharaj… - BioMed research …, 2015 - Wiley Online Library
Early detection of ovarian cancer through screening may have impact on mortality from the
disease. Approaches based on CA125 cut‐off have not been effective. Longitudinal …

[HTML][HTML] Ovarian cancer risk reduction through opportunistic salpingectomy

JS Kwon - Journal of Gynecologic Oncology, 2015 - synapse.koreamed.org
Janice S. Kwon http://dx. doi. org/10.3802/jgo. 2015.26. 2.83 84 www. ejgo. org ovarian
reserve, although there was no difference in the total number of follicles and oocytes …

[HTML][HTML] Delayed presentation of patients with gynaecological malignancies in Kano, North-Western Nigeria

N Adamou, UA Umar - Open Journal of Obstetrics and Gynecology, 2015 - scirp.org
The diagnosis and management of gynaecological cancers are still challenging in low-and
middle-income countries. In patients with gynaecological malignancies delay at any point …

[PDF][PDF] Fluorescence analysis of urine and its potential for ovarian cancer screening

D Martinicky, M Zvarik, L Sikurova, I Lajdova… - Neoplasma, 2015 - academia.edu
We analysed urine from 42 healthy volunteers, 35 patients with benign, and 36 patients with
malignant ovarian tumors. Synchronous fluorescence spectra with a 70 nm wavelength …