Muscular dystrophy (MD) refers to a clinically and genetically heterogeneous group of
degenerative muscle disorders characterized by progressive muscle wasting and often …

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We
discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a …

Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disease caused by
dystrophin deficiency. Gene therapy has significantly improved the outcome of dystrophin …

Selenoprotein N (SEPN1) is a broadly expressed resident protein of the endoplasmic
reticulum (ER) whose loss-of-function inexplicably leads to human muscle disease. We …

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting
secondary to repeated muscle damage and inadequate repair. Elevations in intracellular …

Receptor-activator of NF-κB, its ligand RANKL, and the soluble decoy receptor
osteoprotegerin are the key regulators of osteoclast differentiation and bone remodeling …

Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically
characterized by centrally located nuclei, central aggregation of oxidative activity, and type I …

We have performed microsecond molecular dynamics (MD) simulations and protein pK a
calculations of the muscle calcium pump (sarcoplasmic reticulum Ca 2+-ATPase, SERCA) in …

Duchenne muscular dystrophy (DMD) is a genetic, lethal, muscle disorder caused by the
loss of the muscle protein, dystrophin, leading to progressive loss of muscle fibers and …

Muscular dystrophy is accompanied by a reduction in activity of sarco/endoplasmic reticulum
Ca 2+-ATPase (SERCA) that contributes to abnormal Ca 2+ homeostasis in …