The march toward malaria vaccines
SL Hoffman, J Vekemans, TL Richie, PE Duffy - Vaccine, 2015 - Elsevier
In 2013 there were an estimated 584,000 deaths and 198 million clinical illnesses due to
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …
malaria, the majority in sub-Saharan Africa. Vaccines would be the ideal addition to the …
[HTML][HTML] Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines
TL Richie, PF Billingsley, BKL Sim, ER James… - Vaccine, 2015 - Elsevier
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …
Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers …
GP Gómez-Pérez, A Legarda, J Muñoz, BKL Sim… - Malaria journal, 2015 - Springer
Background Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool
for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only …
for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only …
[HTML][HTML] Large screen approaches to identify novel malaria vaccine candidates
Until recently, malaria vaccine development efforts have focused almost exclusively on a
handful of well characterized Plasmodium falciparum antigens. Despite dedicated work by …
handful of well characterized Plasmodium falciparum antigens. Despite dedicated work by …
[HTML][HTML] Whole organism blood stage vaccines against malaria
DI Stanisic, MF Good - Vaccine, 2015 - Elsevier
Despite a century of research focused on the development and implementation of effective
control strategies, infection with the malaria parasite continues to result in significant …
control strategies, infection with the malaria parasite continues to result in significant …
[HTML][HTML] Optimizing intradermal administration of cryopreserved Plasmodium falciparum sporozoites in controlled human malaria infection
KE Lyke, MB Laurens, K Strauss, M Adams… - The American journal …, 2015 - ncbi.nlm.nih.gov
Controlled human malaria infection (CHMI) is a powerful tool to evaluate malaria vaccine
and prophylactic drug efficacy. Until recently CHMI was only carried out by the bite of …
and prophylactic drug efficacy. Until recently CHMI was only carried out by the bite of …
Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium …
Background A vaccine that interrupts malaria transmission (VIMT) would be a valuable tool
for malaria control and elimination. One VIMT approach is to identify sexual erythrocytic and …
for malaria control and elimination. One VIMT approach is to identify sexual erythrocytic and …
Workshop report: Malaria vaccine development in Europe–preparing for the future
NK Viebig, F D'Alessio, SJ Draper, BKL Sim… - Vaccine, 2015 - Elsevier
The deployment of a safe and effective malaria vaccine will be an important tool for the
control of malaria and the reduction in malaria deaths. With the launch of the 2030 Malaria …
control of malaria and the reduction in malaria deaths. With the launch of the 2030 Malaria …