The same, only different–DNA damage checkpoints and their reversal throughout the cell cycle
IA Shaltiel, L Krenning, W Bruinsma… - Journal of cell …, 2015 - journals.biologists.com
Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …
Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family
Tandem C2H2-type zinc finger proteins (ZFPs) constitute the largest transcription factor
family in animals. Tandem-ZFPs bind DNA in a sequence-specific manner through arrays of …
family in animals. Tandem-ZFPs bind DNA in a sequence-specific manner through arrays of …
hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells
PJ Thompson, V Dulberg, KM Moon, LJ Foster… - PLoS …, 2015 - journals.plos.org
Retrotransposition of endogenous retroviruses (ERVs) poses a substantial threat to genome
stability. Transcriptional silencing of a subset of these parasitic elements in early mouse …
stability. Transcriptional silencing of a subset of these parasitic elements in early mouse …
Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9
B Yu, S Swatkoski, A Holly, LC Lee… - Proceedings of the …, 2015 - National Acad Sciences
The small GTPase KRAS is frequently mutated in human cancer and currently there are no
targeted therapies for KRAS mutant tumors. Here, we show that the small ubiquitin-like …
targeted therapies for KRAS mutant tumors. Here, we show that the small ubiquitin-like …
LMP1-induced sumoylation influences the maintenance of Epstein-Barr virus latency through KAP1
GL Bentz, CR Moss, CB Whitehurst, CA Moody… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT As a herpesvirus, Epstein-Barr virus (EBV) establishes a latent infection that can
periodically undergo reactivation, resulting in lytic replication and the production of new …
periodically undergo reactivation, resulting in lytic replication and the production of new …
[HTML][HTML] High levels of KAP1 expression are associated with aggressive clinical features in ovarian cancer
Y Cui, S Yang, X Fu, J Feng, S Xu, G Ying - International journal of …, 2015 - mdpi.com
KAP1 is an universal corepressor for Kruppel-associated box zinc finger proteins in both
normal and tumor cells. In this study, the biological function and clinical significance of KAP1 …
normal and tumor cells. In this study, the biological function and clinical significance of KAP1 …
KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair
YH Lin, J Yuan, H Pei, T Liu, DK Ann, Z Lou - PloS one, 2015 - journals.plos.org
Homologous recombination and non-homologous end joining are two major DNA double-
strand-break repair pathways. While HR-mediated repair requires a homologous sequence …
strand-break repair pathways. While HR-mediated repair requires a homologous sequence …
[HTML][HTML] Expression of KAP1 in epithelial ovarian cancer and its correlation with drug-resistance
M Hu, X Fu, Y Cui, S Xu, Y Xu, Q Dong… - International journal of …, 2015 - ncbi.nlm.nih.gov
KAP1 is a universal corepressor for Kruppel-associated box zinc finger proteins. In this
study, expression level of KAP1 and its association with drug resistance and expression of P …
study, expression level of KAP1 and its association with drug resistance and expression of P …
LMTK3 represses tumor suppressor-like genes through chromatin remodeling in breast cancer
Y Xu, H Zhang, N Angelopoulos, J Nunes, A Reid… - Cell reports, 2015 - cell.com
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer,
including breast, lung, gastric, and colorectal cancer. It is localized in different cellular …
including breast, lung, gastric, and colorectal cancer. It is localized in different cellular …
[HTML][HTML] ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer
K Chen, G Yu, K Gumireddy, A Li, W Yao, L Gao… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Inactivation or mutation of the VHL gene causes various tumors, including clear cell renal
cell carcinoma (ccRCC). In the present study, we identified ZBRK1 as a novel VHL …
cell carcinoma (ccRCC). In the present study, we identified ZBRK1 as a novel VHL …