[HTML][HTML] The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies
HJ Chon, KJ Bae, Y Lee, J Kim - Frontiers in pharmacology, 2015 - frontiersin.org
The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in
treatment of various human cancers. CK2 overexpression has been demonstrated in …
treatment of various human cancers. CK2 overexpression has been demonstrated in …
Protein Kinase CK2: A Targetable BCR‐ABL Partner in Philadelphia Positive Leukemias
BCR‐ABL‐mediated leukemias, either Chronic Myeloid Leukemia (CML) or Philadelphia
positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular …
positive Acute Lymphoblastic Leukemia (ALL), are the paradigm of targeted molecular …
[HTML][HTML] Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer
MR Sarduy, I García, MA Coca, A Perera… - British journal of …, 2015 - nature.com
Background: We conducted a phase 1 trial in patients with locally advanced cervical cancer
by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to …
by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to …
[HTML][HTML] Synthesis, biological evaluation and molecular modeling of substituted indeno [1, 2-b] indoles as inhibitors of human protein kinase CK2
F Alchab, L Ettouati, Z Bouaziz, A Bollacke, JG Delcros… - Pharmaceuticals, 2015 - mdpi.com
Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked
great interest for the design of ATP-competitive inhibitors of human CK2. In the present …
great interest for the design of ATP-competitive inhibitors of human CK2. In the present …
[HTML][HTML] Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth
Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in
multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma. Here, we …
multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma. Here, we …
Protein kinase CK2 and dysregulated oncogenic inflammatory signaling pathways
EN Benveniste, GK Gray, BC McFarland - Protein kinase CK2 cellular …, 2015 - Springer
Near simultaneously with the explosive expansion in the understanding of CK2's prodigious
promiscuity, the kinase was and has been implicated in a large number of cancers through a …
promiscuity, the kinase was and has been implicated in a large number of cancers through a …
Effects of CK2 inhibition in cultured fibroblasts from Type 1 Diabetic patients with or without nephropathy
CK2 is a multifunctional, pleiotropic protein kinase involved in the regulation of cell
proliferation and survival. Since fibroblasts from Type 1 Diabetes patients (T1DM) with …
proliferation and survival. Since fibroblasts from Type 1 Diabetes patients (T1DM) with …
[图书][B] Chemical Biology Approaches to Investigate the Activity and Substrate Specificity of Protein Kinase CK2
MA Gabriel - 2015 - search.proquest.com
Protein kinase CK2 is a constitutively active, acidophilic protein serine/threonine kinase with
an extensive array of protein substrates that have been implicated in the regulation of many …
an extensive array of protein substrates that have been implicated in the regulation of many …
Analysis of Protein Kinase CK2 in B-lymphopoiesis and lymphomagenesis in a mouse conditional Knockout model
F Zaffino - 2015 - research.unipd.it
Serine-threonine protein kinase CK2 has been recently involved in the pathogenesis of B-
cell tumors, such as B acute lymphoblastic leukemia, B chronic lymphocytic leukemia …
cell tumors, such as B acute lymphoblastic leukemia, B chronic lymphocytic leukemia …