Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have
acquired multidrug resistance and cause infections that are effectively untreatable present a …

Molecular modelling and simulations have been employed to study the membranes of Gram-
negative bacteria for over 20 years. Proteins native to these membranes, as well as …

Pyoverdine I (PVDI) and pyochelin (PCH) are the two major siderophores produced by
Pseudomonas aeruginosa PAO1 to import iron. The biochemistry of the biosynthesis of …

Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium responsible for severe
infections in which resistance to most of the approved families of antibiotics is increasing …

Detergents are widely used for the isolation and solubilization of membrane proteins to
support crystallization and structure determination. Detergents are amphiphilic molecules …

A series of novel ferrichrome (FC) analogs was designed based on the X-ray structure of FC
in the FhuA transporter of Escherichia coli. Two strategies were employed: the first strategy …

Pseudomonas aeruginosa is a versatile environmental microorganism that also causes life-
threatening opportunistic infections. At the root of this bacterium's ability to survive in such …

Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized
and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their …

Le fer est un nutriment essentiel à la vie de tout organisme vivant, des bactéries jusqu'à
l'homme. En dépit de ce rôle clé dans le vivant, le fer à forte concentration est toxique. Dans …

The Gram-negative bacterium Pseudomonas aeruginosa, a ubiquitous human opportunistic
pathogen, has developed resistances to multiple antibiotics. It uses its primary native …