Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver
necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion …

Necroptosis is a recently described Caspase 8-independent method of cell death that
denotes organized cellular necrosis. The roles of RIP1 and RIP3 in mediating hepatocyte …

Metabolic activation and oxidant stress are key events in the pathophysiology of
acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative stress triggered by …

Acetaminophen (APAP) is widely used as a safety analgesic and antipyretic agent. Although
considered safe at therapeutic doses, overdose of APAP can cause acute liver injury that is …

Withaferin-A (WA) has anti-oxidant activities however, its therapeutic potential in
acetaminophen (APAP) hepatotoxicity is unknown. We performed a proof-of-concept study …

Statement of Retraction We, the Editors and Publisher of the journal Cell Cycle, have
retracted the following article: Yongtao Xiao, Weihui Yan, Lina Lu, Ying Wang, Wei Lu, Yi …

The ever-increasing presence of pharmaceutical drugs in the environment is a motif of
concern, and human-use drugs are of particular importance. This is the case of paracetamol …

The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here,
we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) …

Ethnopharmacological relevance Vitex doniana fruits are locally used in Nigeria as a
remedy in the treatment of jaundice and liver related disease. The effect of methanolic …

AIM: To investigate the hepatoprotective effects and mechanisms of hydrogen-rich water
(HRW) in acetaminophen (APAP)-induced liver injury in mice. METHODS: Male mice were …