Cartilage repair using hydrogels: a critical review of in vivo experimental designs

CA Vilela, C Correia, JM Oliveira… - ACS Biomaterials …, 2015 - ACS Publications
This review analyzes the outcomes and technical aspects of in vivo studies published in the
past decade using gels and hydrogels for cartilage repair. Using PubMed search engine …

Therapeutic potential of differentiated mesenchymal stem cells for treatment of osteoarthritis

O Ham, CY Lee, R Kim, J Lee, S Oh, MY Lee… - International journal of …, 2015 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, and irreversible degenerative joint disease.
Conventional OA treatments often result in complications such as pain and limited activity …

Chondrogenic potential of injectable κ‐carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue‐engineering applications

EG Popa, SG Caridade, JF Mano… - Journal of tissue …, 2015 - Wiley Online Library
Due to the limited self‐repair capacity of cartilage, regenerative medicine therapies for the
treatment of cartilage defects must use a significant amount of cells, preferably applied using …

Hypoxic culture of bone marrow-derived mesenchymal stromal stem cells differentially enhances in vitro chondrogenesis within cell-seeded collagen and hyaluronic …

TD Bornes, NM Jomha, A Mulet-Sierra… - Stem cell research & …, 2015 - Springer
Introduction The quality of cartilaginous tissue derived from bone marrow mesenchymal
stromal stem cell (BMSC) transplantation has been correlated with clinical outcome …

Multiscale biofabrication of articular cartilage: bioinspired and biomimetic approaches

PD Tatman, W Gerull, S Sweeney-Easter… - … Engineering Part B …, 2015 - liebertpub.com
Articular cartilage is the load-bearing tissue found inside all articulating joints of the body. It
vastly reduces friction and allows for smooth gliding between contacting surfaces. The …

[HTML][HTML] Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells

WD Lee, MB Hurtig, RM Pilliar, WL Stanford… - Osteoarthritis and …, 2015 - Elsevier
Objective In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical
integration between articular cartilage and subchondral bone. Recapitulation of this …

Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model

S Araki, S Imai, H Ishigaki, T Mimura… - Acta …, 2015 - Taylor & Francis
Background and purpose—Integration of repaired cartilage with surrounding native cartilage
is a major challenge for successful tissue-engineering strategies of cartilage repair. We …

Isolation and characterization of cd271+ stem cells derived from sheep dermal skin

R Jahroomishirazi, A Bader, S Ebert, C Schmidt… - Cells Tissues …, 2015 - karger.com
Background: Mesenchymal stem cells (MSCs) have great promise in the field of
regenerative medicine due to their differentiation potential into several lineages. Besides the …

High resolution MRI imaging at 9.4 Tesla of the osteochondral unit in a translational model of articular cartilage repair

L Goebel, A Müller, A Bücker, H Madry - BMC musculoskeletal disorders, 2015 - Springer
Background Non-destructive structural evaluation of the osteochondral unit is challenging.
Here, the capability of high-field magnetic resonance imaging (μMRI) at 9.4 Tesla (T) was …

Porous scaffold seeding and chondrogenic differentiation of BMSC-seeded scaffolds

TD Bornes, NM Jomha, A Mulet-Sierra, AB Adesida - Bio-protocol, 2015 - bio-protocol.org
Bone marrow-derived mesenchymal stromal stem cells (BMSCs) are a promising cell source
for treating articular cartilage defects (Bornes et al., 2014). BMSCs can be seeded within …