The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly
understood. In this far-reaching review, we examine what is currently known about ALS …

Spinal muscular atrophy (SMA) is a severe neuromuscular disease, the most common in
infancy, and the third one among young people under 18 years. The major pathological …

The past decade has seen a dramatic increase in the discovery of candidate biomarkers for
ALS. These biomarkers typically can either differentiate ALS from control subjects or predict …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of obscure etiology.
Multiple genetic studies have been conducted to advance our understanding of the disease …

With the acceleration in our understanding of ALS and the related motor neuron disease has
come even greater challenges in reconciling all of the proposed pathogenic mechanisms …

Amyotrophic lateral sclerosis (ALS) is a dreadful, devastating and incurable motor neuron
disease. Aetiologically, it is a multigenic, multifactorial and multiorgan disease. Despite …

肌萎缩侧索硬化症(amyotrophic lateral sclerosis, ALS) 是—种累及脑与脊髓上下运动神经元,
导致肌肉无力, 萎缩, 言语, 吞咽, 呼吸功能障碍的迟发性神经变性疾病[1] …

Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that
primarily affects motor neurons and has no effective treatment. Recently, Iida et al. identified …

Amyotrophic lateral sclerosis is sporadic (SALS) in 90% of cases and has complex
environmental and genetic influences. Nogo protein inhibits neurite outgrowth and is …