Current methods for detection of copy number variants (CNV) and aberrations (CNA) from
targeted sequencing data are based on the depth of coverage of captured exons. Accurate …

Temozolomide (TMZ) increases the overall survival of patients with glioblastoma (GBM), but
its role in the clinical management of diffuse low-grade gliomas (LGG) is still being defined …

For 150 years or more, specimens were routinely collected and deposited in natural history
collections without preserving fresh tissue samples for genetic analysis. In the case of most …

Multifocal breast cancer (MFBC), defined as multiple synchronous unilateral lesions of
invasive breast cancer, is relatively frequent and has been associated with more aggressive …

Current genomic studies are limited by the poor availability of fresh-frozen tissue samples.
Although formalin-fixed diagnostic samples are in abundance, they are seldom used in …

Objective Endometrial carcinoma (EC) is the sixth most common cancer in women and
therapies are limited for advanced and recurrent disease. Patient-derived tumor xenograft …

Current whole genome amplification (WGA) methods lead to amplification bias resulting in
over-and under-represented regions in the genome. Nevertheless, certain WGA methods …

Objective To add evidence that massive parallel sequencing (MPS) is a valuable substitute
for array comparative genomic hybridization (arrayCGH) with a resolution that is more …

Cancer cell lines are good in vitro models to study molecular mechanisms underlying
chemoresistance and cancer recurrence. Recent works have demonstrated that most of the …

As one of the most recent advanced technologies developed for biomedical research, the
next generation sequencing (NGS) technology has opened more opportunities for scientific …